A common stomach bacteria found in two thirds of the world population may be linked to a higher risk of Alzheimer’s disease, new research suggests.
The study investigated whether a clinically apparent Helicobacter pylori (H. pylori) infection increased the risk of Alzheimer’s disease in people aged 50 and older. The prevalent infection can trigger indigestion, gastritis, ulcers, and even stomach cancer.
The researchers analyzed health data of over 4 million people in the United Kingdom aged 50 and above between 1988 and 2019. They found that people with symptomatic H. pylori infection had an 11% higher risk of developing Alzheimer’s disease, the most common type of dementia.
While the cause of Alzheimer’s disease is multifaceted, the findings build upon a growing body of evidence on the potential role of infections, particularly H. Pylori, in its development.
The study opens avenues for future research, particularly exploring whether eradicating this bacterium could effectively prevent Alzheimer’s disease in some people.
Alzheimer’s disease affects millions of people globally, with numbers expected to rise sharply as demographics shift, say researchers.
“Given the global aging population, dementia numbers are expected to triple in the next 40 years. However, there remains a lack of effective treatment options for this disease,” says Paul Brassard, the study’s senior author and a professor in McGill University’s medicine department.
“We hope the findings from this investigation will provide insight on the potential role of H. pylori in dementia in order to inform the development of prevention strategies, such as individualized eradication programs, to reduce infections at the population level,” says Brassard, a public health and preventive medicine physician at the McGill University Health Centre.
The study appears in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Funding for the study came from a project grant from the Canadian Institutes of Health Research (CIHR).
Source: McGill University
