A new discovery from a study with mice indicates one of the possible mechanisms that lets LSD increase social interaction.
The findings, which could help unlock potential therapeutic applications in treating certain psychiatric diseases, including anxiety and alcohol use disorders, appear in the Proceedings of the National Academy of Sciences.
Psychedelic drugs, including LSD, were popular in the 1970s and have been gaining popularity over the past decade, with reports of young professionals claiming to regularly take small non-hallucinogenic micro-doses of LSD to boost their productivity and creativity and to increase their empathy. The mechanism of action of LSD on the brain, however, has remained a mystery.
To conduct their study, the researchers administered a low dose of LSD (lysergic acid diethylamide) to mice over a period of seven days, resulting in an observable increase in the sociability of the mice. “This increased sociability occurs because the LSD activates the serotonin 5-HT2A receptors and the AMPA receptors—which is a glutamate receptor, the main brain excitatory neurotransmitters—in the prefrontal cortex and also activates a cellular protein called mTORC 1,” explains Danilo De Gregorio, a postdoctoral fellow in the Neurobiological Psychiatry Unit at McGill University and the study’s first author.
“These three factors, taken together, promote social interaction in mice, which is the equivalent of empathy and social behavior in humans.”
The researchers note that the main outcome of their study is the ability to describe, at least in rodents, the underlying mechanism for the behavioral effect that results in LSD increasing feelings of empathy, including a greater connection to the world and sense of being part of a large community.
“The fact that LSD binds the 5-HT2A receptor was previously known. The novelty of this research is to have identified that the prosocial effects of LSD activate the 5-HT2 receptors, which in-turn activate the excitatory synapses of the AMPA receptor as well as the protein complex mTORC1, which has been demonstrated to be dysregulated in diseases with social deficits such as autism spectrum disorder,” as specified by Nahum Sonenberg, professor in McGill’s biochemistry department and co-lead author of the study.
Using the cutting-edge technique of optogenetics, a technique where genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using light signals, the researchers observed that when the excitatory transmission in the prefrontal cortex is de-activated, the prosocial effect of LSD was nullified, highlighting the importance of this brain region on the modulation of the behavioral effects of LSD.
Having found that LSD increases social interaction in mice, the researchers are hoping to continue their work and to test the ability of LSD to treat mutant mice displaying the behavioral deficits similar to those seen in human pathologies including autism spectrum disorders and social anxiety disorders. The hope is to eventually explore whether micro-doses of LSD or some novel derivates might have a similar effect in humans and whether it could also be a viable and safe therapeutic option.
“Social interaction is a fundamental characteristic of human behavior,” notes co-lead author Gabriella Gobbi, professor in the psychiatry department and psychiatrist at the McGill University Health Centre. “These hallucinogenic compounds, which, at low doses, are able to increase sociability may help to better understand the pharmacology and neurobiology of social behavior and, ultimately, to develop and discover novel and safer drugs for mental disorders.”
Source: McGill University
