The same thing that lets high performance athletes “feel the burn” makes people with chronic fatigue syndrome feel exhausted by the most common daily activities.
New research suggests that the neural pathways that transmit feelings of fatigue to the brain might be doing their job a little too well in some people. The findings also provide evidence that peripheral tissues such as muscles contribute to feelings of fatigue.
Researchers say figuring out the origins of fatigue could help develop therapies for people with the disease.
Muscle metabolism
Chronic fatigue syndrome, which the Institute of Medicine recently renamed systemic exertion intolerance disease, or SEID, is characterized by extreme chronic fatigue. Because its chief symptom—fatigue—is often associated with many other diseases, it can be difficult to diagnose for the more than one million people who actually have it, the Centers for Disease Control and Prevention says.
The disease has no root medical cause, and researchers don’t know what triggers it. But they are studying aspects of the disease to figure out ways to treat it.
The new study focuses on the role of muscle metabolites, including lactic acid and adenosine triphosphate, or ATP, in the disease. It demonstrated for the first time that these substances, released when a person exercises muscles, seem to activate these neural pathways. Also, the pathways seem to be much more sensitive in patients with chronic fatigue syndrome than in patients without the disease, something that hasn’t been studied before.
“What we have shown now, that has never been shown before in humans, is that muscle metabolites can induce fatigue in healthy people as well as patients who already have fatigue,” says Roland Staud, professor of rheumatology and clinical immunology at University of Florida College of Medicine and lead author of a paper in the journal Pain.
Highly-sensitive pathways
During exercise, muscles produce metabolites, which are sensed by metaboreceptors that transmit information via fatigue pathways to the brain, according to the researchers. But in patients with SEID, these fatigue pathways have become highly sensitive to metabolites and can trigger excessive feelings of fatigue.
“For most of us, at the end of strenuous exertion we feel exhausted and need to stop—but we will recover rapidly,” Staud says. “However, these individuals tire much more rapidly and sometimes just after moving across a room, they are fully exhausted. This takes a toll on their lives.”
For the study, Staud and coauthor Michael E. Robinson, professor in the department of clinical and health psychology, recruited a group of 39 patients with SEID and 29 participants without the disease. Participants wore a blood pressure cuff just above their elbows on their dominant side and squeezed a spring-loaded device with 100 percent of their maximum capacity, which was measured by a dial.
They then squeezed the device so that the dial showed they were gripping at 50 percent of their maximum capacity for as long as they could.
At the end of the hand-grip exercise, the blood pressure cuff on the participant’s arm was inflated, almost instantly trapping the metabolites generated by the exercise within the forearm muscles. This allowed the metabolites to collect in the forearm tissue without being cleared by the circulatory system. There, the metabolites continued to activate fatigue pathways, sending messages of fatigue to the brain and allowing researchers to measure how much fatigue and pain may occur because of the trapped metabolites.
With the blood pressure cuff still inflated, the participants rated fatigue and then pain in their forearms every 30 seconds. Both patients with SEID and patients without the disease reported increasing fatigue, but patients with the disease recorded much higher levels of fatigue and pain.
More fatigue, more pain
“We found that the fatigued individuals reported more fatigue than the non-fatigued individuals during the exercise, and also found that they had more pain compared to the non-fatigued individuals,” Staud says.
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On the Fatigue Visual Analog Scale used to measure participants’ fatigue, patients with SEID rated their fatigue at approximately 5.5 on a scale of 0 to 10 after the hand-grip exercise while wearing the inflated blood pressure cuff, whereas participants without the disease rated their fatigue at approximately 1.5.
After 30 minutes, the participants repeated the exercise, but with the opposite arm and without the cinching blood pressure cuff so the metabolites could be cleared from the arm. Both sets of participants experienced fatigue, but the feeling of fatigue in those with the disease was much lower than when the metabolites were trapped with the blood pressure cuff.
“This suggests that hypersensitive fatigue pathways play an important role for the often pronounced exercise-related fatigue of patients with the disease,” Staud says.
Staud next plans to explore treatment interventions and to conduct brain-imaging studies of patients with SEID.
“The take-home message here is, like many of the pain studies we have conducted, there are both peripheral and central nervous system factors at play in these complex syndromes,” Robinson says, “Our study seems to highlight the important role of these peripheral tissues.”
Source: University of Florida
